Just put in the remaining necessary cache headers on my kungfu club mobile site and I ran a YSlow! test on it and it got a 100! I've never had that before.
Admittedly, this is like cheating since the site is for mobile use it's kept very very simple and has no external dependencies so no need for a CDN. Getting a Grade A on YSlow! is very hard if the site needs to really blink. This one is built dedicated for small mobile phone screens on slow connections. I think now the bottleneck isn't in the rendering but in the connection latency for the remote database.
It also got a 4.9 (max 5.0) on ready.mobi which is the highest I've ever achieved there.